Extra copies of chromosome 1q and how they help cancers grow
Genomic and functional approaches to characterize Chr1q gains in cancer
Researchers will use genome data and lab experiments to find how extra copies of part of chromosome 1 (called 1q) help cancers grow and to look for weak spots that could be treated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11419094 on NIH RePORTER |
What this research studies
The team will analyze tumor genome data to identify cancers across types that carry Chr1q gains. In the lab they will use cancer cell lines and genetic tools, including CRISPR-based methods, to mimic or reverse 1q dosage changes and watch how cells respond. Computational analyses will be combined with functional tests to pinpoint which genes on 1q create tumor dependencies. The goal is to find specific vulnerabilities or biomarkers linked to 1q amplification that could guide future treatments or tests.
Who could benefit from this research
Good fit: People whose tumors show extra copies of chromosome 1q—such as some breast cancer patients—would be most relevant for providing samples or joining future related trials.
Not a fit: Patients without 1q amplification or those needing immediate clinical therapy are unlikely to receive direct benefit from this laboratory-focused work.
Why it matters
Potential benefit: If successful, this could reveal targetable weaknesses in tumors with 1q gains and inform new therapies or diagnostic tests.
How similar studies have performed: Targeting single oncogene dependencies has been successful before, but experimentally manipulating whole chromosome-arm gains like 1q is a relatively new and less-tested approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Sheltzer, Jason — Stanford University
- Study coordinator: Sheltzer, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.