Exploring why certain brain cells are more vulnerable in Parkinson's Disease
Understanding Cell-type Vulnerability and Oxidative Stress Pathology in Parkinson's Disease Using Isogenic Human Dopaminergic Neurons
This study is looking at why certain brain cells that help with movement are especially vulnerable in Parkinson's Disease, using advanced stem cell models to find out how stress and genetics play a role, with the hope of discovering new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10986026 on NIH RePORTER |
What this research studies
This research investigates the specific vulnerability of dopaminergic neurons in the brain, which are crucial for motor function and are significantly affected in Parkinson's Disease (PD). By using advanced human stem cell models, the study aims to understand how oxidative stress and genetic factors contribute to the degeneration of these neurons. The researchers will analyze the cellular mechanisms that make these neurons particularly susceptible to damage, with the goal of identifying new therapeutic targets. Patients may benefit from insights that could lead to more effective treatments for PD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Parkinson's Disease, particularly those with a family history of the condition.
Not a fit: Patients with Parkinson's Disease who do not have a genetic predisposition or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting vulnerable brain cells in Parkinson's Disease, potentially improving treatment outcomes.
How similar studies have performed: Other research has shown promising results in understanding neurodegeneration through similar cellular models, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Blanchard, Joel William — Icahn School of Medicine at Mount Sinai
- Study coordinator: Blanchard, Joel William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.