Exploring ways to extend lifespan by combining growth hormone antagonism with other compounds
Official title: Combining GHR antagonism with life extending compounds: a search for synergies
Funded at Ohio University Athens · NIH-11077885 · Data updated 2026-11-12
This study is looking at how a special treatment that blocks growth hormone can work together with other compounds to help slow down aging and keep you healthier as you get older, using animal models to find the best combinations that might one day benefit people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 1, 2018 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $613,541 |
| NIH project number | 5R01AG059779-08 |
| Project ID | NIH-11077885 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing age-related health issues or those interested in interventions that may promote healthy aging.
✕Less likely to help
Patients who are not experiencing age-related conditions or those who are younger and not yet affected by aging may not receive direct benefits from this research.
What this research studies
This research investigates how combining a growth hormone receptor antagonist with various life-extending compounds can potentially slow the aging process and prevent age-related diseases. The approach focuses on targeting multiple biological pathways simultaneously to enhance health and lifespan. By utilizing animal models, the study aims to identify effective combinations that outperform single treatments. Patients may benefit from insights gained about interventions that could improve their health as they age.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly extend healthy lifespan and reduce the burden of age-related diseases.
How similar studies have gone: Previous studies have shown promising results with similar combination therapies in animal models, indicating potential for success in this novel approach.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Kopchick, John Joseph — Ohio University Athens
- Study coordinator: Kopchick, John Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.