Exploring treatments for mild traumatic brain injury from blasts
Official title: Non-selective membrane channel blockers for mTBI
Funded at James J Peters VA Medical Center · NIH-10954268 · Data updated 2026-11-12
This study is looking at how mild traumatic brain injuries from blasts affect veterans, using rats to understand the brain problems like PTSD and depression that can come from these injuries, with the hope of finding better treatments to help those who are struggling.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I21RX004886-02 |
| Project ID | NIH-10954268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans who have experienced mild traumatic brain injuries from blast exposure and are suffering from related cognitive or mental health issues.
✕Less likely to help
Patients who have not experienced blast-related injuries or those with other types of brain injuries may not benefit from this research.
What this research studies
This research investigates the effects of blast-induced mild traumatic brain injury (mTBI), particularly among veterans who have experienced such injuries during military service. The study utilizes a rat model to simulate the chronic cognitive and mental health issues associated with mTBI, such as PTSD and depression. By examining the underlying inflammatory processes in the brain, the research aims to identify potential pharmacological treatments that could address these issues more effectively than current options. The findings could lead to improved therapeutic strategies for managing the long-term consequences of blast-related injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the quality of life for veterans suffering from chronic cognitive and mental health disorders due to mTBI.
How similar studies have gone: Previous research has shown promising results in using animal models to understand and treat the effects of traumatic brain injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Cardozo, Christopher P — James J Peters VA Medical Center
- Study coordinator: Cardozo, Christopher P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.