Exploring the use of tiny vesicles called exosomes for treating inflammation-related diseases.
BLRD Merit Review Research Career Scientist Award
This study is looking at how tiny particles called exosomes can help deliver treatments for inflammation-related diseases like brain inflammation, obesity, rheumatoid arthritis, and liver issues in veterans, with the hope of making these conditions easier to manage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisville VA Medical Medical Center NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11063280 on NIH RePORTER |
What this research studies
This research investigates the role of exosomes, which are tiny vesicles released from various cells, as potential therapeutic vehicles for treating inflammation-related diseases in veterans. The focus is on conditions such as brain inflammation, obesity, rheumatoid arthritis, and nonalcoholic fatty liver disease. By targeting the delivery of therapeutic agents specifically to microglia, the research aims to improve treatment outcomes for these challenging conditions. The study builds on extensive prior work, with over 60 published manuscripts supporting the investigation of these innovative treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans experiencing inflammation-related conditions such as Gulf War Syndrome, rheumatoid arthritis, or obesity.
Not a fit: Patients with non-inflammatory conditions or those not affiliated with the VA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for veterans suffering from chronic inflammatory diseases.
How similar studies have performed: Previous research has shown promise in using exosomes for therapeutic delivery, indicating potential for success in this novel approach.
Where this research is happening
Louisville, United States
- Louisville VA Medical Medical Center — Louisville, United States (Active)
Researchers
- Principal investigator: Zhang, Huang-Ge — Louisville VA Medical Medical Center
- Study coordinator: Zhang, Huang-Ge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.