Exploring the use and safety of a new antipsychotic for agitation in elderly patients with dementia
Official title: Determining the Utilization, Cost, and Safety of Antipsychotics Among the Elderly with Dementia Post-Brexpiprazole Approval for Agitation in Alzheimer's Disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11039404 · Data updated 2026-11-12
This study looks at how well brexpiprazole, a new medication for helping older adults with Alzheimer's and related conditions who feel restless or agitated, is being used in real life, including how much it costs and how safe it is, to see if it can make life better for both patients and their caregivers.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $443,838 |
| NIH project number | 1R21AG091282-01 |
| Project ID | NIH-11039404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals diagnosed with Alzheimer's disease or related dementias who experience agitation.
✕Less likely to help
Patients who do not have Alzheimer's disease or related dementias, or those who do not exhibit agitation, may not benefit from this research.
What this research studies
This research investigates the use of brexpiprazole, the first FDA-approved medication for treating agitation in elderly patients with Alzheimer's disease and related dementias. It aims to assess how often this medication is prescribed, its associated costs, and its safety profile in real-world settings. By analyzing data on its utilization, the study seeks to understand the implications of this new treatment option for improving the quality of life for patients and reducing caregiver burden. The research will involve collecting and analyzing information from various healthcare settings to provide insights into the medication's effectiveness and safety.
Why it matters
Potential benefit: If successful, this research could lead to improved management of agitation in elderly patients with dementia, enhancing their quality of life and supporting caregivers.
How similar studies have gone: Other research has shown promising results with the use of antipsychotics for managing agitation in dementia patients, but this specific approach with brexpiprazole is relatively novel.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Kim, Youngran — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kim, Youngran
Related research
Other NIH-funded projects on the same topics.
-
Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
-
Automated language analysis for Alzheimer’s disease and frontotemporal dementia in Latino and English speakers
A low-cost, automated speech and language analysis tool is being developed to help identify Alzheimer’s disease or frontotemporal dementia in Latino and English-speaking people.
-
Automated language analysis for Alzheimer’s and frontotemporal dementia across Latino and English-speaking groups
A low-cost, automated language study aims to help diagnose and understand Alzheimer’s and FTD in diverse Spanish- and English-speaking communities.
-
Automated language analysis to help diagnose Alzheimer’s and frontotemporal dementia in Latino and English speakers
A low-cost, computer-based method analyzes speech and language to help identify Alzheimer’s disease or frontotemporal dementia in Latino and English-speaking people.
-
Automated language analysis for Alzheimer's and frontotemporal dementia in Latino and English-speaking communities
A low-cost, computer-based language analysis method is being developed to help identify Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking people.
-
Automated language analysis to detect Alzheimer’s and frontotemporal dementia in Latino and English-speaking adults
A low-cost, computer-based language and speech analysis tool will help identify Alzheimer’s disease and frontotemporal dementia in Latino and English-speaking adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.