Exploring the structure and function of specific brain receptors involved in various diseases
Probing the structure and function of the intracellular domain of cys-loop receptors
This study is looking at special brain receptors that help with communication between nerve cells, and it's trying to find new ways to create better treatments for conditions like Alzheimer's and anxiety, which could help many patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Tech University Health Scis Center NIH-funded |
| Lab location | 1 site (Lubbock, United States) |
| Project ID | NIH-10988249 on NIH RePORTER |
What this research studies
This research investigates the intracellular domain of pentameric ligand-gated ion channels, which are important receptors in the brain for neurotransmitters like acetylcholine and serotonin. By understanding how these receptors function and interact with other proteins, the research aims to identify new drug targets that could help treat neuropsychiatric and neurological conditions. The approach includes detailed structural analysis and characterization of these receptors, which have been largely overlooked in previous studies. Patients may benefit from advancements in treatments for conditions such as Alzheimer's disease and anxiety disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neuropsychiatric conditions, such as Alzheimer's disease or anxiety disorders.
Not a fit: Patients with conditions unrelated to the function of pentameric ligand-gated ion channels may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients suffering from neuropsychiatric and neurological disorders.
How similar studies have performed: Previous research has shown promise in understanding similar receptor mechanisms, suggesting potential for success in this novel approach.
Where this research is happening
Lubbock, United States
- Texas Tech University Health Scis Center — Lubbock, United States (Active)
Researchers
- Principal investigator: Jansen, Michaela — Texas Tech University Health Scis Center
- Study coordinator: Jansen, Michaela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.