Exploring the signaling molecules produced by fat cells to understand health and disease.
An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and Disease
This study is looking at the substances released by fat cells to understand how they affect energy use in the body and how problems with these signals might lead to obesity and type 2 diabetes, helping both mice and people live healthier lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10886148 on NIH RePORTER |
What this research studies
This research investigates the secretions of white and brown fat cells, which play crucial roles in energy management and signaling within the body. By creating a comprehensive encyclopedia of the substances these cells release, the study aims to uncover how disruptions in these signals contribute to conditions like obesity and type 2 diabetes. The research will utilize advanced technologies to identify and characterize these secretions in both mouse models and human subjects, providing insights into their functions and responses to stress and disease. This collaborative effort combines basic biology with human investigations to enhance our understanding of metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with obesity or type 2 diabetes who are interested in understanding the biological mechanisms behind their conditions.
Not a fit: Patients who do not have metabolic disorders or those with unrelated health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating obesity and type 2 diabetes.
How similar studies have performed: Previous research has shown promise in understanding adipocyte signaling, but this comprehensive approach to cataloging the adipocyte secretome is novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Cohen, Paul — Rockefeller University
- Study coordinator: Cohen, Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.