Exploring the roles of specific lipids in the cell nucleus
Official title: Unexpected roles of phosphoinositides in the nucleus
Funded at University of Nebraska Medical Center · NIH-10897258 · Data updated 2026-11-12
This study is looking at how certain fats in our cells, called phosphoinositides, work in the cell's nucleus and how they might play a role in diseases like autoimmune disorders and cancer, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $364,490 |
| NIH project number | 5R35GM150504-02 |
| Project ID | NIH-10897258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with autoimmune diseases, neurodegenerative disorders, or cancers that may be influenced by phosphoinositide signaling.
✕Less likely to help
Patients with conditions unrelated to phosphoinositide signaling or those not affected by the diseases being studied may not benefit from this research.
What this research studies
This research investigates the functions of phosphoinositides, a type of lipid, within the nucleus of cells. It aims to understand how these lipids influence cell signaling and contribute to various diseases, including autoimmune disorders and cancer. By identifying the interactions between phosphoinositides and other proteins, the research seeks to uncover new pathways that could be targeted for therapeutic interventions. Patients may benefit from insights gained about disease mechanisms and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to phosphoinositide signaling.
How similar studies have gone: While the role of phosphoinositides in cellular signaling is established, the specific focus on their nuclear functions is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Choi, Suyong — University of Nebraska Medical Center
- Study coordinator: Choi, Suyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.