Exploring the roles of pregnancy-specific glycoproteins in maternal-fetal immune interactions
Not all members of the pregnancy-specific glycoprotein family are created equal
This study is looking at how special proteins from the placenta help a pregnant woman's immune system work with her baby’s unique genes, which could help improve outcomes for moms and babies, especially in cases like preeclampsia and preterm birth.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10615689 on NIH RePORTER |
What this research studies
This research investigates how proteins secreted by the placenta, known as pregnancy-specific glycoproteins (PSGs), influence the immune system during pregnancy. It focuses on understanding the evolutionary adaptations that allow mothers and their genetically different fetuses to coexist without immune rejection. By examining the regulation of inflammation and immune cell responses, particularly in conditions like preeclampsia and preterm birth, the study aims to uncover the distinct functions of different PSGs. This could lead to insights into how these proteins can be targeted to improve pregnancy outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals, particularly those at risk for complications like preeclampsia.
Not a fit: Patients who are not pregnant or those with no history of pregnancy complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing complications in pregnancy, such as preeclampsia and preterm birth.
How similar studies have performed: Previous research has shown that understanding immune interactions during pregnancy can lead to significant advancements in maternal-fetal medicine, suggesting this approach has potential for success.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Dveksler, Gabriela S — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Dveksler, Gabriela S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.