Exploring the role of triple-stranded RNA in cancer biology
Characterization of a Model System to Advance Triple-Stranded RNA Biology
This study is looking at a special type of RNA called MALAT1 and how it works with a protein named METTL16, which could help us learn more about important processes in our cells and potentially lead to new ways to understand and treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-10669618 on NIH RePORTER |
What this research studies
This research investigates the biological functions of triple-stranded RNA, particularly focusing on a specific RNA structure known as MALAT1 and its interaction with a protein called METTL16. By using advanced techniques like X-ray crystallography and biochemical methods, the researchers aim to uncover how these molecules interact and their roles in critical processes such as telomere synthesis and RNA splicing. This foundational knowledge could lead to the development of new tools for discovering additional RNA triple helices and understanding their significance in cancer biology.
Who could benefit from this research
Good fit: Patients with malignancies or cancers that may be influenced by RNA biology, particularly those related to the MALAT1 RNA structure.
Not a fit: Patients with conditions unrelated to RNA biology or those not affected by malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating cancers associated with RNA biology.
How similar studies have performed: While the exploration of RNA triple helices is a relatively novel area, preliminary findings suggest potential for significant breakthroughs in understanding RNA biology.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Brown, Jessica Ann — University of Notre Dame
- Study coordinator: Brown, Jessica Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.