Exploring the role of specific RNA sequences and proteins in Alzheimer's disease
Official title: Identifying and understanding the role of repeat RNAs and RAN proteins in Alzheimer's disease
Funded at University of Florida · NIH-11076315 · Data updated 2026-11-12
This study is looking at how certain genetic factors and proteins might play a role in Alzheimer's disease, and it invites patients to help by sharing genetic samples or taking part in assessments to help researchers learn more about how these factors relate to memory and thinking changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $242,712 |
| NIH project number | 5R00AG065511-05 |
| Project ID | NIH-11076315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are experiencing cognitive decline or have a family history of Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the potential role of repeat RNAs and RAN proteins in the development and progression of Alzheimer's disease. By examining genetic factors and protein accumulation associated with Alzheimer's, the study aims to uncover new insights into the disease's pathology. Patients may be involved in providing genetic samples or participating in assessments that help researchers understand the relationship between these molecular factors and cognitive decline. The approach combines genetic analysis with clinical evaluations to better understand how these elements contribute to Alzheimer's symptoms.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools or therapeutic strategies for Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors contributing to neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Nguyen, Lien — University of Florida
- Study coordinator: Nguyen, Lien
Related research
Other NIH-funded projects on the same topics.
-
Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model
Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.
-
Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients
A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.
-
Non-invasive tears biomarker for early Alzheimer's in LMICs
A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.
-
Turning APOE4 into protective APOE2 or APOE3Christchurch to help with Alzheimer’s
A patient-facing explanation of a treatment idea that aims to change a genetic risk factor for Alzheimer's disease in the brain.
-
Telomerase in Alzheimer’s Disease: how aging biology could influence memory and brain health
Researchers are exploring a new brain-aging mechanism linked to telomerase, with potential to slow or modify Alzheimer’s disease in people and improve cognitive function.
-
Biomarkers of Alzheimer’s Disease: Sensory, Motor, and Cognitive Clues
Researchers are testing simple sensory and movement tasks to find early signs of Alzheimer’s disease so they can diagnose and treat people sooner.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.