Exploring the role of specific cells in the developing human intestinal stem cell environment
Official title: Interrogating sub-epithelial cell heterogeneity in the developing human intestinal stem cell niche
Funded at University of Michigan at Ann Arbor · NIH-10990468 · Data updated 2026-11-12
This study is looking at how certain cells in your intestines help keep stem cells healthy and help them grow, which could lead to better ways to repair and develop the intestines.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,040 |
| NIH project number | 5F32DK138694-02 |
| Project ID | NIH-10990468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting the intestines or those interested in the biology of intestinal stem cells.
✕Less likely to help
Patients with stable, non-progressive gastrointestinal conditions may not receive direct benefits from this research.
What this research studies
This research investigates how specialized cells in the human intestine contribute to the maintenance and regeneration of intestinal stem cells. By utilizing advanced techniques like single-cell RNA sequencing and organoid culture models, the study aims to identify the unique signals and environments that support these stem cells. The focus is on understanding the heterogeneity of sub-epithelial cells and their role in the intestinal niche, which could lead to insights into organ repair and development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of intestinal health and lead to new therapies for bowel-related diseases.
How similar studies have gone: Previous research has shown promise in understanding stem cell niches, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Johnson, Kelli — University of Michigan at Ann Arbor
- Study coordinator: Johnson, Kelli
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.