Exploring the role of phosphorylated biomolecules in human health
Reagents for Chemical Oligophosphorylation, Synthesis of Oligophosphate-Organic Molecule Conjugates, and Biochemical Studies
This study is working on creating new tools to help scientists understand how certain chemical changes in our bodies affect health, which could lead to better treatments for diseases related to these changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10551903 on NIH RePORTER |
What this research studies
This research focuses on the synthesis of chemical probes that contain specific lengths of oligophosphate chains, which are crucial for understanding the role of phosphorylation in human physiology. By developing new reagents for the phosphorylation of organic molecules, the research aims to create tools that can help explore the human polyP-ome, a complex network of phosphorylated biomolecules. Patients may benefit from advancements in this area as it could lead to better understanding and treatment of diseases linked to phosphorylation processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular function and phosphorylation abnormalities.
Not a fit: Patients with conditions unrelated to phosphorylation or cellular processes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of diseases related to phosphorylation, potentially leading to new therapeutic strategies.
How similar studies have performed: Other research has shown promise in understanding the role of phosphorylation in various biological processes, indicating that this approach could yield valuable insights.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Cummins, Christopher C — Massachusetts Institute of Technology
- Study coordinator: Cummins, Christopher C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.