Exploring the role of phosphorylated biomolecules in health and medicine
Official title: Synthesis and Applications of Oligophosphate Constructs
Funded at Massachusetts Institute of Technology · NIH-11090795 · Data updated 2026-11-12
This study is exploring new chemical tools that can help scientists understand how certain changes in proteins affect our bodies, with the hope that this research will lead to better treatments and tests for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $444,262 |
| NIH project number | 1R35GM158437-01 |
| Project ID | NIH-11090795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to enzyme dysfunction or those requiring advanced biochemical diagnostics.
✕Less likely to help
Patients with conditions unrelated to biochemical processes or those not requiring enzyme-targeted therapies may not benefit from this research.
What this research studies
This research focuses on synthesizing chemical probes that contain oligophosphate chains to study their effects on various biological targets, including proteins and enzymes. By developing new methods for creating these probes, researchers aim to enhance our understanding of post-translational modifications and their implications in human physiology. The project will also investigate how these oligophosphate constructs can be used to inhibit specific enzymes, potentially leading to new therapeutic strategies. Patients may benefit from advancements in drug design and diagnostics stemming from this work.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapies that improve patient outcomes in various health conditions.
How similar studies have gone: Previous research has shown promise in using similar biochemical approaches to develop therapeutic agents, indicating potential for success in this area.
Where this research is happening
-
Massachusetts Institute of Technology
Cambridge, United States Active
Researchers
- Principal investigator: Cummins, Christopher C — Massachusetts Institute of Technology
- Study coordinator: Cummins, Christopher C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.