Exploring the role of oral bacteria in blood infections after stem cell transplants
Official title: Investigating the oral microbiome in hematopoietic cell transplants
Funded at Research Inst Nationwide Children's Hosp · NIH-10951639 · Data updated 2026-11-12
This study is looking at how the bacteria in the mouth can impact kids who are getting stem cell transplants, especially in relation to problems like mouth sores and infections, with the hope of finding ways to better diagnose and prevent these issues.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $170,746 |
| NIH project number | 1R03DE034037-01 |
| Project ID | NIH-10951639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children undergoing hematopoietic cell transplants who are at risk for oral mucositis and bloodstream infections.
✕Less likely to help
Patients who are not undergoing hematopoietic cell transplants or who do not have oral health complications may not benefit from this research.
What this research studies
This research investigates how the oral microbiome affects complications in children undergoing hematopoietic cell transplants (HCT). It focuses on understanding the relationship between oral bacteria and conditions like oral mucositis and bloodstream infections. By conducting a longitudinal study at Nationwide Children’s Hospital, researchers aim to identify specific bacterial species that may contribute to these complications. The goal is to improve diagnostic methods and develop preventive strategies for at-risk patients.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and management of infections in children receiving stem cell transplants.
How similar studies have gone: Previous studies have shown disruptions in the oral microbiome in adults undergoing similar treatments, but this research focuses specifically on children, making it a novel approach.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Lee, Kyulim — Research Inst Nationwide Children's Hosp
- Study coordinator: Lee, Kyulim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.