Exploring the role of NMDARs in the development of neural crest cells
Novel functions for NMDARs in neural crest development
This study is looking at how certain receptors in the brain affect the growth and movement of special cells that help form important parts of the body, like facial bones and nerves, which could help us understand some developmental disorders better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10645523 on NIH RePORTER |
What this research studies
This research investigates how N-Methyl-D-Aspartate receptors (NMDARs) influence the development of neural crest cells, which are crucial for forming various tissues in the body, including craniofacial cartilage and parts of the peripheral nervous system. The study will utilize mutant models lacking specific NMDAR subunits to understand their role in cell proliferation and migration. By examining calcium influx and the specific NMDAR subunits involved, the research aims to uncover new mechanisms that regulate neural crest development. This could provide insights into developmental disorders related to these cell types.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to neural crest development, such as craniofacial disorders or certain neurodevelopmental disorders.
Not a fit: Patients with conditions unrelated to neural crest development or those who do not have any craniofacial or peripheral nervous system abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to neural crest development, potentially improving outcomes for patients with craniofacial abnormalities or peripheral nervous system disorders.
How similar studies have performed: While the role of NMDARs in neural development is known, this specific investigation into their function in neural crest cells is novel and has not been extensively studied.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Sirotkin, Howard I — State University New York Stony Brook
- Study coordinator: Sirotkin, Howard I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.