Exploring the role of long noncoding RNAs in human cells
Official title: Identification and Characterization of Functional lncRNAs in human cells
Funded at University of California Berkeley · NIH-11095844 · Data updated 2026-11-12
This study is exploring special RNA molecules called long noncoding RNAs to see how they work in our bodies, using a new technology that helps scientists look at them more easily, which could help us understand their role in health and diseases better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $117,883 |
| NIH project number | 5K99GM151484-02 |
| Project ID | NIH-11095844 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to lncRNA dysregulation, which may include various cancers and genetic disorders.
✕Less likely to help
Patients with conditions unrelated to lncRNA function or those who do not have a genetic component to their disease may not benefit from this research.
What this research studies
This research investigates long noncoding RNAs (lncRNAs), which are crucial components of the human transcriptome involved in various biological processes. The project aims to identify and characterize functional lncRNAs using a novel RNA-targeting CRISPR-Csm technology that allows for efficient knockdown and imaging of these molecules in living cells. By overcoming previous technical limitations, the research will enable high-throughput screening of thousands of lncRNAs, potentially revealing their roles in health and disease. This work could lead to significant advancements in understanding RNA biology and its implications for disease diagnosis and treatment.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of diseases linked to lncRNA dysregulation and pave the way for new diagnostic and therapeutic strategies.
How similar studies have gone: Previous research has shown promising results using CRISPR technology for RNA studies, indicating that this approach has the potential for success.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Colognori, David — University of California Berkeley
- Study coordinator: Colognori, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.