Exploring the role of histone modifications in disease
NIH Administrative Supplement to Purchase a Lyophilizer
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11098855
This study is looking at how certain changes to proteins called histones can affect how our genes work and may play a role in diseases, with the goal of creating new tools to help us better understand these changes and potentially develop targeted treatments for those conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11098855 on ClinicalTrials.gov |
What this research studies
This research investigates how specific chemical modifications of histones, particularly lysine methylation and acylation, affect biological processes and their implications in diseases. By developing new molecular tools, the project aims to enhance our understanding of how these modifications influence gene expression and cellular functions. The research will focus on creating engineered proteins that can selectively bind to these modifications, allowing for improved detection and analysis. This innovative approach could lead to the development of targeted therapies that address diseases linked to these histone modifications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diseases linked to dysregulation of histone modifications.
Not a fit: Patients without conditions related to histone modifications or those not affected by epigenetic changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with histone modifications.
How similar studies have performed: Other research has shown promising results in understanding the role of histone modifications in disease, indicating that this approach has potential for success.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WATERS, MARCEY L — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: WATERS, MARCEY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease