Exploring the role of genetic elements in Alzheimer's Disease and related dementias
Official title: Leveraging large datasets to determine genomic impact of transposable elements in Alzheimer’s Disease and related dementias
Funded at University of Michigan at Ann Arbor · NIH-11136758 · Data updated 2026-11-12
This study is looking at how certain genetic pieces that can move around in our DNA might affect the development of Alzheimer's Disease and similar conditions, with the hope of finding new ways to understand and treat these diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $303,449 |
| NIH project number | 1R03AG087485-01A1 |
| Project ID | NIH-11136758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or related dementias, particularly those with a genetic predisposition.
✕Less likely to help
Patients with non-genetic forms of dementia or those without a diagnosis of Alzheimer's Disease may not benefit from this research.
What this research studies
This research investigates how transposable elements, which are genetic sequences that can change their position within the genome, may influence the development of Alzheimer's Disease (AD) and related dementias. By analyzing large datasets that include genomic sequences and clinical information, the study aims to uncover patterns and impacts of these elements on AD progression. A novel cloud-based infrastructure will be utilized to handle the complex data analysis, allowing for a more comprehensive understanding of the genetic factors involved in AD. The findings could lead to new insights into the mechanisms of AD and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Alzheimer's Disease and lead to improved diagnostic and therapeutic strategies.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors of Alzheimer's Disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Zhou, Weichen — University of Michigan at Ann Arbor
- Study coordinator: Zhou, Weichen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.