Exploring the role of cardiolipin in mitochondrial energy transport
Official title: An intimate and multifaceted partnership: cardiolipin and the mitochondrial ADP/ATP carrier
Funded at Johns Hopkins University · NIH-10987015 · Data updated 2026-11-12
This study is looking at how a special fat called cardiolipin helps energy transporters in our cells work better, which could be important for understanding diseases related to problems with our cell's energy production.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 10, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $454,145 |
| NIH project number | 5R01HL165729-03 |
| Project ID | NIH-10987015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction, such as Barth syndrome or other metabolic disorders.
✕Less likely to help
Patients with non-mitochondrial related conditions or those without any metabolic disorders may not benefit from this research.
What this research studies
This research investigates how cardiolipin, a unique phospholipid found in mitochondrial membranes, interacts with ADP/ATP carriers that are essential for energy production in cells. By studying these interactions, the research aims to uncover the mechanisms by which cardiolipin influences the function of these carriers, which could have implications for various diseases linked to mitochondrial dysfunction. The approach involves detailed biochemical and biophysical analyses to understand the structural roles of cardiolipin in mitochondrial energy transport.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating diseases associated with mitochondrial dysfunction, potentially improving energy metabolism in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function and its relationship with cardiolipin, indicating that this area of study has potential for significant breakthroughs.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Claypool, Steven Michael — Johns Hopkins University
- Study coordinator: Claypool, Steven Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.