Exploring the role of cadherin-11 in lung fibrosis and its treatment
Official title: UNDERSTANDING CADHERIN-11 IN THE DEVELOPMENT AND TREATMENT OF LUNG FIBROSIS
Funded at Baylor College of Medicine · NIH-11031989 · Data updated 2026-11-12
This study is looking at how a protein called cadherin-11 affects lung fibrosis in people with scleroderma, with the hope of finding new ways to help improve treatment for patients dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 10, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $489,729 |
| NIH project number | 5R01AR082635-02 |
| Project ID | NIH-11031989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with scleroderma who are experiencing lung fibrosis.
✕Less likely to help
Patients with lung fibrosis not related to scleroderma or those with other underlying conditions may not benefit from this research.
What this research studies
This research investigates how cadherin-11, a protein involved in cell adhesion, contributes to the development of lung fibrosis associated with scleroderma, an autoimmune disease. The study aims to understand the mechanisms by which cadherin-11 influences the behavior of immune cells and lung cells, potentially leading to new therapeutic targets. Researchers will utilize specialized mouse models to explore these interactions and identify new regulators of fibrosis. The ultimate goal is to develop targeted treatments that could improve outcomes for patients suffering from lung fibrosis.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat lung fibrosis in patients with scleroderma.
How similar studies have gone: Previous research has shown promising results in targeting cell adhesion molecules for treating fibrosis, suggesting that this approach may be viable.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Agarwal, Sandeep K — Baylor College of Medicine
- Study coordinator: Agarwal, Sandeep K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.