Exploring the role of a specific protein pathway in Alzheimer's disease.
Official title: Identification and characterization of the CD31-ApoE-mCRP pathway for Alzheimer's disease in humans.
Funded at Boston University Medical Campus · NIH-10591027 · Data updated 2026-11-12
This study is looking at how a protein in your blood might affect brain cells and contribute to Alzheimer's disease, especially for people with a specific gene variant, to help find better ways to prevent and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $2,404,559 |
| NIH project number | 1RF1AG075832-01A1 |
| Project ID | NIH-10591027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who carry the ApoE4 allele and are at risk for developing Alzheimer's disease.
✕Less likely to help
Patients who do not carry the ApoE4 allele or who have already been diagnosed with advanced Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how a protein called C-reactive protein (CRP) interacts with blood vessel cells in the brain and its potential link to Alzheimer's disease, particularly in individuals with the ApoE4 gene variant. The study aims to understand how this interaction may lead to increased inflammation and cognitive decline in patients. By examining blood samples and brain imaging, researchers hope to uncover the mechanisms that contribute to Alzheimer's risk and progression. This could lead to new insights into prevention and treatment strategies for those at risk of Alzheimer's.
Why it matters
Potential benefit: If successful, this research could provide new targets for therapies aimed at reducing the risk or delaying the onset of Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in understanding the role of inflammation in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Qiu, Wei Qiao Wendy — Boston University Medical Campus
- Study coordinator: Qiu, Wei Qiao Wendy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.