Exploring the relationship between white matter changes and Alzheimer's disease in older adults
Investigating Cellular Neighborhoods and Tissue Architecture in White Matter Hyperintensities
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10998547
This study is looking at changes in the brain that often happen in people over 65, which could help us understand how these changes are related to Alzheimer's disease and other health problems, with the hope of finding better ways to diagnose and treat these conditions.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10998547 on ClinicalTrials.gov |
What this research studies
This research investigates white matter hyperintensities (WMH), which are common in individuals over 65 and linked to increased risks of Alzheimer's disease and other health issues. By utilizing advanced MRI techniques on postmortem brain tissue, the study aims to uncover the cellular and tissue characteristics of WMH and their connection to cerebrovascular health. The goal is to better understand how these changes in brain structure relate to the onset and progression of Alzheimer's disease, potentially leading to improved diagnostic and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those with or at risk for Alzheimer's disease.
Not a fit: Patients younger than 65 or those without any signs of cognitive decline or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of Alzheimer's disease and related conditions in older adults.
How similar studies have performed: Previous research has shown promising results in understanding white matter changes in relation to Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JULIAN, DANA — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: JULIAN, DANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia