Exploring the potential of microbial phosphonic acids for new medicines
Genomics-Accelerated Discovery and Biosynthesis of Phosphonic Acid Natural Products
This study is exploring natural substances made by microbes that could help create new antibiotics to fight infections, especially those that are hard to treat, so that patients can have better options for their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10889059 on NIH RePORTER |
What this research studies
This research investigates microbial phosphonic acids, which are natural products with promising antimicrobial, antiviral, and antimalarial properties. By analyzing the genetic and biochemical mechanisms behind these compounds, the project aims to uncover new pathways and enzymes that can lead to the development of novel antibiotics. Patients may benefit from this research as it seeks to enhance the discovery and engineering of new antimicrobial agents that could combat resistant infections. The approach involves isolating new compounds and understanding their biosynthesis through advanced genomic techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria or those at risk of such infections.
Not a fit: Patients who do not have infections or are not at risk of antibiotic-resistant infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections resistant to current medications.
How similar studies have performed: Other research has shown promise in utilizing microbial natural products for antibiotic development, indicating a potential for success in this area.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Ju, Kou-San — Ohio State University
- Study coordinator: Ju, Kou-San
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.