Exploring the potential of FANCM to treat BRCA1-related breast and ovarian cancer
Therapeutic potential of FANCM for BRCA1-linked cancer
This study is looking at how a special protein helps fix DNA in breast and ovarian cancers caused by BRCA1 mutations, using a new method to see how cancer cells react to treatment, with the hope of finding better therapies for patients who need them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10930975 on NIH RePORTER |
What this research studies
This research investigates the role of FANCM, a protein involved in DNA repair, in treating breast and ovarian cancers linked to BRCA1 mutations. The study utilizes a novel CRISPR-based approach to induce specific DNA damage in cancer cells, allowing researchers to analyze how these cells respond to treatment. By understanding the mechanisms of genomic instability in BRCA1-related cancers, the research aims to identify new therapeutic strategies that could overcome resistance to existing treatments. Patients may benefit from more effective and targeted therapies as a result of this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast or ovarian cancer who have BRCA1 mutations.
Not a fit: Patients without BRCA1 mutations or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with BRCA1-linked breast and ovarian cancers.
How similar studies have performed: Previous research has shown promise in using CRISPR technology for cancer treatment, indicating that this approach could yield significant advancements.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Panday, Arvind — Mayo Clinic Rochester
- Study coordinator: Panday, Arvind
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.