Exploring the pain-relieving effects of terpenes and THC
Analgesic and subjective effects of terpenes administered alone and in combination with THC: Potential THC- and opioid-sparing effects of myrcene and ß-caryophyllene
This study is looking at how certain natural compounds called terpenes, like myrcene and ß-caryophyllene, might boost the pain relief from THC while making side effects less intense, and it’s for people dealing with chronic pain who are interested in new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11281244 on NIH RePORTER |
What this research studies
This research investigates how terpenes, specifically myrcene and ß-caryophyllene, can enhance the pain-relieving effects of THC while potentially reducing its side effects. By examining the interactions between these compounds, the study aims to determine if terpenes can provide effective pain relief on their own or in combination with low doses of THC. The research will also assess the safety and potential for abuse of these compounds, which is crucial for developing new treatments for chronic pain. Patients may be involved in trials to evaluate these effects in a clinical setting.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals suffering from chronic pain who are seeking alternative pain management therapies.
Not a fit: Patients who do not experience chronic pain or those who are not interested in cannabinoid-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective pain management options for patients with chronic pain.
How similar studies have performed: Previous research has shown promising results with terpenes in animal models, but this study aims to confirm their effects in humans, making it a novel investigation.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cooper, Ziva D — University of California Los Angeles
- Study coordinator: Cooper, Ziva D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.