Exploring the pain-relieving effects of terpenes and THC
Analgesic and subjective effects of terpenes administered alone and in combination with THC: Potential THC- and opioid-sparing effects of myrcene and ß-caryophyllene
This study is looking at how two natural compounds, myrcene and ß-caryophyllene, might boost the pain relief from THC while making its side effects milder, and it’s for people dealing with chronic pain who are interested in safer alternatives to opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10794216 on NIH RePORTER |
What this research studies
This research investigates how terpenes, specifically myrcene and ß-caryophyllene, can enhance the pain-relieving effects of THC while potentially reducing its side effects. The study aims to determine if these terpenes can provide effective pain relief on their own or when combined with low doses of THC, which is known for its psychoactive properties. By examining the interaction between terpenes and THC, the research seeks to develop safer cannabinoid-based treatments for chronic pain, addressing the current opioid crisis. Participants may be involved in trials assessing the effectiveness and safety of these compounds.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain who are seeking alternative pain relief methods.
Not a fit: Patients who do not experience chronic pain or those who are not interested in cannabinoid-based therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective pain management options for patients suffering from chronic pain.
How similar studies have performed: Previous research has shown promising results with terpenes in preclinical models, but this study aims to confirm their effects in human subjects, making it a novel exploration.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cooper, Ziva D — University of California Los Angeles
- Study coordinator: Cooper, Ziva D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.