Exploring the links between TDP-43 pathology and neurodegenerative diseases
Connecting TDP-43 Pathology to the Molecular Profiles of Neurodegeneration
This study is looking at how problems with a protein called TDP-43 might affect people with Alzheimer's and frontotemporal dementia, by examining tissue samples from over 200 patients to see how certain changes in the brain could be linked to these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10611809 on NIH RePORTER |
What this research studies
This research investigates the role of TDP-43 protein dysfunction in common neurodegenerative diseases like Alzheimer's Disease and frontotemporal dementia. By analyzing tissue samples from over 200 patients, the researchers aim to identify specific molecular pathways that are altered in these conditions. The study focuses on understanding how retrotransposons may contribute to the toxicity associated with TDP-43 dysfunction. Patients' samples will be characterized to uncover distinct transcriptional profiles and their relationship to disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with frontotemporal dementia or Alzheimer's Disease.
Not a fit: Patients with neurodegenerative diseases not associated with TDP-43 pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of neurodegeneration, potentially informing future treatments for Alzheimer's and frontotemporal dementia.
How similar studies have performed: Previous research has shown promising results in understanding TDP-43 pathology in ALS, suggesting that this approach may yield valuable insights for dementia as well.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Gale Hammell, Molly — New York University School of Medicine
- Study coordinator: Gale Hammell, Molly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.