Exploring the links between dental health and overall disease
Official title: Leveraging All of Us data to unravel the interconnectedness between dental and systemic disease
Funded at University of Pittsburgh at Pittsburgh · NIH-10918307 · Data updated 2026-11-12
This study is looking at how dental problems like cavities and gum disease might be linked to other health issues such as diabetes and heart disease, and it invites patients to share their health information to help us learn more about how taking care of your teeth can affect your overall health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $159,000 |
| NIH project number | 5R03DE033541-02 |
| Project ID | NIH-10918307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of dental issues or systemic diseases, particularly those involved in the All of Us Research Program.
✕Less likely to help
Patients without any dental or systemic health issues may not receive direct benefits from this research.
What this research studies
This research investigates how dental diseases, such as cavities and periodontal disease, may be connected to systemic health issues like diabetes and cardiovascular diseases. By analyzing a large dataset from the All of Us Research Program, which includes clinical, genomic, and demographic information from over 200,000 participants, the study aims to uncover shared genetic factors that may influence both dental and systemic health. Patients may contribute to this research by providing their health data, which could lead to a better understanding of how oral health impacts overall health.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for both dental and systemic diseases.
How similar studies have gone: Previous studies have shown promising results in understanding the connections between dental and systemic diseases, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Letra, Ariadne M — University of Pittsburgh at Pittsburgh
- Study coordinator: Letra, Ariadne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.