Exploring the links between brain iron levels and cognitive health in Alzheimer's disease
Identifying Associations between Brain Iron, Neurocognitive Networks and Protective Factors
This study is looking at how iron buildup in the brain might affect thinking and memory in older adults with Alzheimer's disease, and it will also see if eating a diet rich in antioxidants can help slow down this iron buildup and its impact on brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11058540 on NIH RePORTER |
What this research studies
This research investigates how brain iron accumulation affects cognitive networks and contributes to Alzheimer's disease (AD) pathology. By using advanced neuroimaging techniques, the study aims to identify the relationship between brain iron levels and cognitive decline in older adults. It will also explore whether an antioxidant-rich diet can slow down brain iron accumulation and its associated cognitive effects. The research involves assessing 140 healthy older adults through various imaging and biomarker analyses.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy older adults who are concerned about cognitive health or have a family history of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved biomarkers for Alzheimer's disease and strategies to mitigate cognitive decline.
How similar studies have performed: Other research has shown promising results in understanding the role of brain iron in cognitive decline, making this approach both relevant and potentially impactful.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Gold, Brian Timothy — University of Kentucky
- Study coordinator: Gold, Brian Timothy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.