Exploring the link between Y chromosome loss and Alzheimer's disease risk
Official title: Investigating Genomic Instability and Loss of the Y Chromosome in Alzheimer’s Disease
Funded at University of Miami School of Medicine · NIH-10740136 · Data updated 2026-11-12
This study is looking at how losing the Y chromosome as men age might be linked to developing Alzheimer's disease, and it invites men to help by sharing genetic samples to better understand this connection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $422,125 |
| NIH project number | 1R21AG079196-01A1 |
| Project ID | NIH-10740136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are older males who may be at risk for Alzheimer's disease due to genetic factors.
✕Less likely to help
Patients who are not male or who do not have a family history of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how the loss of the Y chromosome in aging males may contribute to the development of Alzheimer's disease. By examining genetic factors and their relationship to Alzheimer's pathology, the study aims to uncover the biological mechanisms behind this risk. The researchers will utilize genome-wide association studies to identify genetic variants associated with this loss and its implications for brain health. Patients may be involved in providing genetic samples to help understand the connection between genomic instability and Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers for early detection and intervention strategies for Alzheimer's disease.
How similar studies have gone: Previous research has indicated a correlation between genetic factors and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Cukier, Holly N — University of Miami School of Medicine
- Study coordinator: Cukier, Holly N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.