Exploring the link between social networks, inflammation, and depression in rural Uganda
Inflammation, Social Networks, and Depression in Rural Uganda
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10513831
This study is looking at how friendships and social connections can affect depression in adults living in rural Uganda, and it will also explore how inflammation in the body might play a role in this relationship.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10513831 on ClinicalTrials.gov |
What this research studies
This research investigates how social networks influence depression among adults in rural Uganda, particularly focusing on the role of inflammation in this relationship. By measuring changes in social network structures and their impact on mental health, the study aims to uncover the biological mechanisms, such as the levels of inflammatory markers like C-reactive protein and interleukin-6, that may mediate these effects. Participants will be drawn from an ongoing social network cohort study, allowing for a comprehensive analysis of both social and biological factors affecting depression. The findings could provide insights into how improving social connections might alleviate depressive symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older living in rural Uganda who are experiencing symptoms of depression.
Not a fit: Patients who do not reside in rural Uganda or those who are not experiencing depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating depression by enhancing social support systems in vulnerable populations.
How similar studies have performed: Previous research has indicated a correlation between social networks and mental health, but this study aims to explore this relationship in a novel way by incorporating the role of inflammation.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSAI, ALEXANDER C — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: TSAI, ALEXANDER C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.