Exploring the link between oral health and Alzheimer's disease
Oral Cavity and Brain Cross-talk in Alzheimer's Disease
['FUNDING_R01'] · UNIVERSITY OF NORTH DAKOTA · NIH-11081718
This study is looking at how your oral health might affect the progression of Alzheimer's disease, using mice to see if changes in saliva and mouth bacteria could play a role in worsening symptoms, which could help us understand and manage the disease better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NORTH DAKOTA (nih funded) |
| Locations | 1 site (GRAND FORKS, UNITED STATES) |
| Trial ID | NIH-11081718 on ClinicalTrials.gov |
What this research studies
This research investigates how changes in oral health may be related to Alzheimer's disease (AD) progression. It uses transgenic mouse models to study the secretion of amyloid-beta (Aβ) in saliva and the impact of oral microbiome changes on both oral and brain health. By examining these relationships, the research aims to uncover whether poor oral health contributes to the development or worsening of AD symptoms. The findings could lead to new insights into the systemic nature of Alzheimer's disease and its management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or those at risk of developing it, particularly those experiencing oral health issues.
Not a fit: Patients without Alzheimer's disease or significant oral health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Alzheimer's disease through better oral health strategies.
How similar studies have performed: Previous studies have shown promising links between oral health and Alzheimer's disease, suggesting that this research builds on established findings rather than exploring a completely novel area.
Where this research is happening
GRAND FORKS, UNITED STATES
- UNIVERSITY OF NORTH DAKOTA — GRAND FORKS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COMBS, COLIN K — UNIVERSITY OF NORTH DAKOTA
- Study coordinator: COMBS, COLIN K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.