Exploring the link between energy production in cells and fatigue in breast cancer patients undergoing chemotherapy
Unraveling the Associations of Molecular-Genetic Bioenergetics and Chemotherapy-Induced Fatigue Symptoms in Patients with Breast Cancer
This study is looking at how changes in energy production in your cells might be causing fatigue for breast cancer patients like you who are undergoing chemotherapy with anthracycline drugs, and it aims to find ways to help manage that tiredness better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10684326 on NIH RePORTER |
What this research studies
This research investigates how changes in cellular energy production may contribute to fatigue experienced by breast cancer patients receiving chemotherapy, particularly those treated with anthracycline drugs. By examining the molecular and genetic pathways involved in mitochondrial function, the study aims to identify the biochemical mechanisms behind chemotherapy-induced fatigue. Patients will have their blood samples analyzed to assess energy production levels and how these relate to their fatigue symptoms. The goal is to better understand the relationship between energy metabolism and fatigue, potentially leading to improved management strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients currently receiving chemotherapy, particularly those treated with anthracycline-based regimens.
Not a fit: Patients who are not undergoing chemotherapy or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that alleviate fatigue in breast cancer patients undergoing chemotherapy, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between mitochondrial dysfunction and cancer-related fatigue, suggesting that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Hsiao, Chao-Pin — Case Western Reserve University
- Study coordinator: Hsiao, Chao-Pin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.