Exploring the link between depression and genetic risk for Alzheimer's disease
Multi-modal intersection of depression and genetic liability to Alzheimers disease
This study is looking at how depression might be connected to certain genes that could raise the chances of getting Alzheimer's disease, and it's for anyone interested in understanding the links between these two conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11134815 on NIH RePORTER |
What this research studies
This research investigates how depression may be related to genetic factors that increase the risk of developing Alzheimer's disease (AD). By analyzing data from over a million individuals across various cohorts, the study aims to identify genetic variants that contribute to both depression and AD. The researchers will focus on two key risk factors: the presence of the APOE-ε4 gene and family history of Alzheimer's. This approach combines genetic analysis with assessments of depressive symptoms to better understand their relationship and potential shared biological mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry the APOE-ε4 gene and have depressive symptoms.
Not a fit: Patients who do not have a history of depression or Alzheimer's disease, or who do not carry the APOE-ε4 gene, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals at risk of Alzheimer's disease who also experience depression.
How similar studies have performed: Previous research has shown promising results in understanding the genetic links between depression and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Pathak, Gita a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Pathak, Gita a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.