Exploring the implications of unexpected findings in healthy stem cell donors
Official title: Incidental diagnosis of clonal hematopoiesis among healthy, unrelated, hematopoietic stem cell donors: A feasibility study of psychosocial, ethical, and clinical issues
Funded at Sloan-Kettering Inst Can Research · NIH-10987922 · Data updated 2026-11-12
This study is looking at how finding certain genetic changes in healthy people who donate stem cells might affect their health, feelings, and the ethical questions around sharing this information.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 2, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $433,895 |
| NIH project number | 1R21CA287094-01A1 |
| Project ID | NIH-10987922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are healthy adults who have volunteered to donate hematopoietic stem cells.
✕Less likely to help
Patients who are not healthy or who have pre-existing hematologic conditions may not benefit from this research.
What this research studies
This research investigates the psychosocial, ethical, and clinical implications of discovering clonal hematopoiesis (CH) in healthy individuals who volunteer as hematopoietic stem cell donors. Clonal hematopoiesis refers to mutations in blood stem cells that can increase the risk of certain diseases, even though it is not classified as a disease itself. The study aims to understand how these incidental findings affect donors' health outcomes and their psychological well-being, as well as the ethical considerations surrounding the disclosure of such findings. Participants will be engaged in discussions and assessments to evaluate the feasibility of addressing these complex issues.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of health risks associated with clonal hematopoiesis in healthy individuals.
How similar studies have gone: While the implications of clonal hematopoiesis have been explored in other contexts, this specific focus on healthy donors is relatively novel and untested.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Tamari, Roni — Sloan-Kettering Inst Can Research
- Study coordinator: Tamari, Roni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.