Exploring the hidden genetic factors that contribute to cancer risk
Official title: Leveraging the Hidden Genome to Recover the Missing Heritability of Cancer
Funded at Sloan-Kettering Inst Can Research · NIH-10586348 · Data updated 2026-11-12
This study is looking at unique genetic changes that might affect how cancer runs in families, and it aims to find new information that could help doctors better understand cancer risks and create more personalized treatment plans for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 5, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $455,111 |
| NIH project number | 1R21CA270428-01A1 |
| Project ID | NIH-10586348 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cancer or those diagnosed with cancer who are interested in understanding their genetic risk factors.
✕Less likely to help
Patients without a family history of cancer or those whose cancer is not believed to have a genetic component may not benefit from this research.
What this research studies
This research investigates the unexplored genetic variations that may play a significant role in cancer heritability. By utilizing advanced sequencing technologies, the team aims to analyze large datasets to identify rare genetic variants that have been overlooked in previous studies. The methodology involves aggregating these variants to better understand their collective impact on cancer risk across different types. Patients may benefit from insights that could lead to improved risk assessment and personalized treatment options based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cancer genetics, leading to better prevention and treatment strategies for patients.
How similar studies have gone: Other research has shown promise in uncovering hidden genetic factors in various diseases, suggesting that this approach could yield valuable insights in cancer as well.
Where this research is happening
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Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Shen, Ronglai — Sloan-Kettering Inst Can Research
- Study coordinator: Shen, Ronglai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.