Exploring the hidden genetic factors that contribute to cancer risk
Leveraging the Hidden Genome to Recover the Missing Heritability of Cancer
['FUNDING_R21'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10586348
This study is looking at unique genetic changes that might affect how cancer runs in families, and it aims to find new information that could help doctors better understand cancer risks and create more personalized treatment plans for patients.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10586348 on ClinicalTrials.gov |
What this research studies
This research investigates the unexplored genetic variations that may play a significant role in cancer heritability. By utilizing advanced sequencing technologies, the team aims to analyze large datasets to identify rare genetic variants that have been overlooked in previous studies. The methodology involves aggregating these variants to better understand their collective impact on cancer risk across different types. Patients may benefit from insights that could lead to improved risk assessment and personalized treatment options based on their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cancer or those diagnosed with cancer who are interested in understanding their genetic risk factors.
Not a fit: Patients without a family history of cancer or those whose cancer is not believed to have a genetic component may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cancer genetics, leading to better prevention and treatment strategies for patients.
How similar studies have performed: Other research has shown promise in uncovering hidden genetic factors in various diseases, suggesting that this approach could yield valuable insights in cancer as well.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, RONGLAI — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SHEN, RONGLAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Disease, Disorder