Exploring the genetics of treatment-resistant schizophrenia
Uncovering the genetic architecture of extremely treatment-resistant schizophrenia using whole genome sequencing
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10877018
This study is looking at the genes of people with extremely treatment-resistant schizophrenia to better understand their symptoms and find new, personalized treatments that could help them feel better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10877018 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors contributing to extremely treatment-resistant schizophrenia (ETRS), a severe form of the disorder affecting the most severely impacted patients. By recruiting 400 individuals with ETRS from the New York State inpatient system, the study aims to characterize their symptoms and perform whole genome sequencing to identify rare genetic variants. This approach seeks to uncover molecular subtypes of schizophrenia, which could lead to more effective treatments tailored to specific genetic profiles. The findings may provide insights into the biological mechanisms underlying this complex condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with extremely treatment-resistant schizophrenia who have not responded to standard treatments.
Not a fit: Patients with schizophrenia who respond well to conventional treatments are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients with treatment-resistant schizophrenia.
How similar studies have performed: Previous research has shown success in identifying genetic factors in other complex disorders, suggesting potential for breakthroughs in understanding schizophrenia.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZOGHBI, ANTHONY — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: ZOGHBI, ANTHONY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder, Cancers