Exploring the genetic links between resilience, PTSD, depression, and Alzheimer's disease.
BLR&D Research Career Development Transition Award Application
This study is looking at how our genes and brain chemistry affect our ability to cope with stress, PTSD, depression, and even Alzheimer's disease, with the hope of finding new ways to help people feel better and improve their mental health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Northern California Health Care Sys NIH-funded |
| Lab location | 1 site (Mather, United States) |
| Project ID | NIH-10948095 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular factors that contribute to psychological resilience, PTSD, and depression, and how these factors may also relate to Alzheimer's disease dementia. Dr. Aliza Wingo, a psychiatrist at the Atlanta VA Medical Center, aims to uncover the shared and distinct mechanisms among these mental health conditions. By studying genetic variants and brain expression levels, the research seeks to identify new pathways for enhancing resilience and developing therapies for PTSD, depression, and Alzheimer's. The findings could lead to innovative treatment strategies that improve mental health outcomes for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing PTSD, depression, or those at risk for Alzheimer's disease, particularly older adults.
Not a fit: Patients with no history of PTSD, depression, or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance psychological resilience and improve treatment options for PTSD, depression, and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors related to resilience and mental health conditions, suggesting that this approach has potential for success.
Where this research is happening
Mather, United States
- VA Northern California Health Care Sys — Mather, United States (Active)
Researchers
- Principal investigator: Wingo, Aliza Pham — VA Northern California Health Care Sys
- Study coordinator: Wingo, Aliza Pham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.