Exploring the genetic links between childhood cancers and birth defects.
Official title: U24-Uncovering the Shared Genetic Origins of Childhood Cancer and Structural Birth Defects Through Enhanced Data Integration and Analysis with the CFDE Data Distillery Knowledge Graph.
Funded at Children's Hosp of Philadelphia · NIH-10994331 · Data updated 2026-11-12
This study is looking into the genetic reasons why some kids get both childhood cancers and birth defects, and it aims to help families understand more about these health issues by analyzing data from affected children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,489,695 |
| NIH project number | 1U24OD038422-01 |
| Project ID | NIH-10994331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with childhood cancers or structural birth defects, as well as their families.
✕Less likely to help
Patients who do not have a diagnosis of childhood cancers or structural birth defects may not benefit from this research.
What this research studies
This research aims to uncover the genetic factors that may explain why some children develop both childhood cancers and structural birth defects. By integrating and analyzing extensive genomic data from affected children, the project will enhance a knowledge graph that connects various data points related to these conditions. The approach involves using advanced machine learning techniques to identify patterns and relationships in the data, which could lead to a better understanding of these complex health issues. Families with children affected by these conditions may find this research particularly relevant as it seeks to provide insights into their origins.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and targeted therapies for childhood cancers and birth defects.
How similar studies have gone: Previous research has shown promise in identifying genetic links between various health conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Taylor, Deanne Marie — Children's Hosp of Philadelphia
- Study coordinator: Taylor, Deanne Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.