Exploring the genetic factors of late-onset Alzheimer's disease using advanced cell analysis techniques.
Untangling the diversity in the genetic architecture of late-onset Alzheimer's disease using single cell multi-omics
This study is looking at how genes and brain cells work in people with late-onset Alzheimer's disease from different backgrounds to help us understand what causes the disease and how it affects different groups of people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10452296 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms behind late-onset Alzheimer's disease (LOAD) by analyzing brain cells from diverse populations. Using advanced single-cell multi-omics techniques, the study aims to identify specific genes and genetic variants that contribute to the disease. By focusing on both European and African ancestries, the research seeks to uncover how gene regulation and epigenomic signatures differ across ethnic groups, which could lead to a better understanding of the disease's pathology. Patients' brain samples will be analyzed to provide insights into the cellular changes associated with LOAD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with late-onset Alzheimer's disease, particularly those from diverse ethnic backgrounds.
Not a fit: Patients with early-onset Alzheimer's disease or those without a diagnosis of Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for late-onset Alzheimer's disease.
How similar studies have performed: Previous research has shown success in using genome-wide association studies to identify genetic factors in Alzheimer's, but this approach is novel in its focus on diverse populations and single-cell analysis.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Chiba-Falek, Ornit — Duke University
- Study coordinator: Chiba-Falek, Ornit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.