Exploring the epigenome using advanced techniques to understand cell states
Expansion genomics for high-resolution single-cell and spatial epigenomics
This study is exploring how tiny changes in our genes affect our cells as we grow, age, and face diseases, using new techniques to get a closer look at these changes, which could help us better understand and treat various health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10945335 on NIH RePORTER |
What this research studies
This research focuses on understanding how the epigenome influences various cell states during development, aging, and disease. It employs innovative techniques like Expansion Genomics to physically expand biological samples, allowing for more detailed measurements of the epigenome at single-cell resolution. By combining expansion with existing methods, the research aims to enhance the accuracy and accessibility of epigenomic analysis, ultimately providing insights into gene regulation. Patients may benefit from improved understanding of their conditions through advancements in epigenomic technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to epigenetic changes, such as certain cancers, neurodegenerative diseases, or age-related disorders.
Not a fit: Patients with conditions not influenced by epigenetic factors or those who do not have access to the research facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases by providing deeper insights into gene regulation.
How similar studies have performed: Other research has shown promise in using advanced genomic techniques to study epigenetics, suggesting that this approach could yield significant insights.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Buenrostro, Jason Daniel — Harvard University
- Study coordinator: Buenrostro, Jason Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.