Exploring the effects of nicotinamide on placental development and preeclampsia
Benefits of nicotinamide in placental development and in preeclamsia
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11093411
This study is looking at whether nicotinamide, a type of vitamin B3, can help improve pregnancy outcomes for women at risk of preeclampsia by understanding how it affects the placenta and a specific protein involved in the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11093411 on ClinicalTrials.gov |
What this research studies
This research investigates how nicotinamide, a form of vitamin B3, may influence placental development and the condition known as preeclampsia, which affects many pregnancies. The study focuses on understanding the molecular mechanisms behind preeclampsia, particularly the role of a peptide called endothelin-1. By using mouse models, the researchers aim to determine if nicotinamide can improve pregnancy outcomes by reducing harmful effects associated with high levels of endothelin-1. Patients may benefit from insights gained about potential treatments for preeclampsia.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who are at risk of developing preeclampsia or have been diagnosed with the condition.
Not a fit: Patients who are not pregnant or those who do not have a risk of preeclampsia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for preeclampsia, potentially improving outcomes for mothers and their babies.
How similar studies have performed: Previous research has shown promising results with similar approaches, indicating that nicotinamide may have beneficial effects in related conditions.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, FENG — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: LI, FENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.