Exploring the effects of HIV, opioids, and amyloid fibrils on brain cells
Intersection of HIV, Opiods, and Amyloid Fibrils in a CNS Organoid Model
This study is looking at how HIV-1 infection and opioid use affect brain cells, especially in relation to memory and thinking, to help find new ways to treat problems that can arise from these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10818416 on NIH RePORTER |
What this research studies
This research investigates how HIV-1 infection, opioid use, and amyloid fibrils interact and affect brain cells, particularly focusing on microglia, astrocytes, and neurons. Using advanced cell culture techniques, including induced pluripotent stem cells (iPSCs) and organoids, the study aims to understand the cellular responses and interactions in a controlled environment. By examining these factors, the research seeks to shed light on neurocognitive decline and inflammation associated with HIV-1 and opioid use, providing insights into potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV-1, particularly those who also use opioids or are experiencing cognitive decline.
Not a fit: Patients who do not have HIV-1 or opioid use issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive decline in patients with HIV and opioid use disorders.
How similar studies have performed: While the intersection of these specific factors is relatively novel, previous research has shown success in studying individual components like HIV and neurocognitive effects, suggesting potential for meaningful insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Swanstrom, Ronald I — Univ of North Carolina Chapel Hill
- Study coordinator: Swanstrom, Ronald I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.