Exploring the effects of high-frequency brain stimulation on behavior
Investigating circuit-specific effects of high-frequency repetitive transcranial magnetic stimulation
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10948925
This study is looking at how a special brain treatment called rTMS can help improve behavior by changing certain brain cells in a way that might benefit people with neurological and mental health issues.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10948925 on ClinicalTrials.gov |
What this research studies
This research investigates how high-frequency repetitive transcranial magnetic stimulation (rTMS) affects specific brain circuits and their role in improving behavior. Using a novel rodent model, the study aims to understand the changes in excitatory neurons in the prefrontal cortex that may lead to better outcomes for patients with neurological and psychiatric disorders. By employing advanced neuroscience techniques, the research will quantify structural changes in the brain that occur with chronic rTMS treatment. The goal is to uncover the mechanisms behind the therapeutic effects of rTMS, which could lead to more effective treatments for various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from major depression or obsessive-compulsive disorder who may benefit from noninvasive brain stimulation therapies.
Not a fit: Patients with conditions unrelated to neurological or psychiatric disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for major depression and other psychiatric disorders by enhancing the effectiveness of rTMS.
How similar studies have performed: Previous research has shown promising results with rTMS in treating depression, indicating that this approach has potential for success.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GONGWER, MICHAEL W. — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: GONGWER, MICHAEL W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.