NIH-funded research R21 grant

Exploring the effects of brief low oxygen levels on recovery after stroke

Official title: Novel Actions of Acute Intermittent Hypoxia in Hemispheric Stroke

Funded at Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · NIH-10575870 · Data updated 2026-11-12

This study is looking at a new way to help stroke survivors recover by using short bursts of reduced oxygen levels, which might boost their muscle strength and movement, making rehabilitation more effective.

More Stroke research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionRehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
NIH-funded
Lab location1 site (Chicago, United States)
Project startSeptember 1, 2022
Project endAugust 31, 2025
Funding year2022
Award (this year)$453,750
NIH project number1R21NS130367-01
Project IDNIH-10575870 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who have experienced a hemispheric stroke and have residual limb impairments.

Less likely to help

Patients who have not had a stroke or those with severe comorbidities that prevent participation in rehabilitation may not benefit from this research.

What this research studies

This research investigates a new treatment approach called Acute Intermittent Hypoxia (AIH) to help improve recovery in stroke patients. AIH involves short periods of reduced oxygen levels, which may stimulate brain pathways and enhance the production of a protein that supports nerve growth and repair. The study aims to measure how this treatment affects muscle activation and strength in the limbs of stroke survivors, potentially leading to better rehabilitation outcomes. By building on previous findings in spinal cord injury patients, the research seeks to determine the effectiveness of AIH in promoting recovery after a stroke.

Why it matters

Potential benefit: If successful, this research could lead to improved rehabilitation strategies for stroke patients, enhancing their recovery and quality of life.

How similar studies have gone: Previous research has shown promising results using similar approaches in spinal cord injury patients, indicating potential for success in stroke rehabilitation.

Where this research is happening

  • Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
    Chicago, United States
    Active

Researchers

  • Principal investigator: Rymer, William Zev — Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab
  • Study coordinator: Rymer, William Zev

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.