Exploring the diverse roles of plasminogen in blood and its interactions with small RNA molecules
Official title: Novel functions of plasminogen and its diverse cargo in blood
Funded at Vanderbilt University Medical Center · NIH-11064066 · Data updated 2026-11-12
This study is looking at how a protein called plasminogen, which helps with blood clotting, also plays a role in carrying fats and tiny RNA molecules in the blood, and it could help us understand how cells communicate and affect health in different ways.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $350,000 |
| NIH project number | 5R01HL173598-02 |
| Project ID | NIH-11064066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions affecting blood function or immune response, particularly those with hypercholesterolemia.
✕Less likely to help
Patients with unrelated conditions or those not experiencing issues with blood or immune system functions may not benefit from this research.
What this research studies
This research investigates the multifunctional roles of plasminogen, a protein traditionally known for its role in blood clotting, in transporting lipids and small non-coding RNAs (sRNAs) in the bloodstream. The study employs advanced techniques such as size-exclusion chromatography and mass spectrometry to identify lipid-based ribonucleoprotein complexes. By examining how plasminogen interacts with immune cells and influences gene expression, the research aims to uncover new mechanisms of intercellular communication that could impact various health conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions related to blood and immune system function.
How similar studies have gone: Other research has shown promising results in understanding the roles of proteins like plasminogen in cellular communication, suggesting potential for success in this area.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Vickers, Kasey C — Vanderbilt University Medical Center
- Study coordinator: Vickers, Kasey C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.