Exploring the connections between a protein linked to Parkinson's disease and RNA binding proteins
Investigating physiologic and pathophysiologic connections between the Parkinson's disease protein alpha-synuclein and RNA binding proteins
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10890170
This study is looking at how a protein linked to Parkinson's disease affects brain cells and their ability to manage important molecules, with the hope of finding new ways to help people with Alzheimer's and similar conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10890170 on ClinicalTrials.gov |
What this research studies
This research investigates how the protein alpha-synuclein, which is associated with Parkinson's disease and related dementias, interacts with RNA binding proteins in neurons. The study aims to understand the mechanisms by which alpha-synuclein contributes to neurotoxicity and disrupts RNA homeostasis, which may lead to neurodegeneration. By examining these interactions, the research seeks to uncover potential pathways that could be targeted for therapeutic interventions in Alzheimer's disease and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, Lewy Body Dementia, or Parkinson's disease with dementia.
Not a fit: Patients with other forms of dementia not related to Alzheimer's or Lewy Body pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for Alzheimer's disease and related dementias by targeting the mechanisms of neurotoxicity.
How similar studies have performed: Previous research has shown promising results in understanding the role of alpha-synuclein in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHURANA, VIKRAM — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: KHURANA, VIKRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease and related dementia, Alzheimer's disease and related disorders, Alzheimer's disease or a related dementia, Alzheimer's disease or a related disorder, Alzheimer's disease or related dementia