Exploring the connection between stroke and Alzheimer's disease through cellular mechanisms

Who could benefit from this research

What this research studies

This research investigates how stroke may increase the risk of developing Alzheimer's disease by examining the molecular changes that occur in neurons after a stroke. It focuses on the role of the actin cytoskeleton and how its alterations can affect neuronal health and survival. By understanding these cellular processes, the research aims to uncover the long-term impacts of stroke on brain function and the development of neurodegenerative diseases. Patients may benefit from insights that could lead to new therapeutic strategies for preventing or treating Alzheimer's disease.

Why it matters

Where this research is happening

• University of Rhode Island
  Kingston, United States Active

Researchers

• Principal investigator: Fallini, Claudia — University of Rhode Island
• Study coordinator: Fallini, Claudia

Related research

Other NIH-funded projects on the same topics.

• Investigating how breathing problems after a stroke affect thinking skills in older adults with Alzheimer's disease.

  This study is looking at how breathing problems after a stroke might affect thinking and memory in older adults, especially those with Alzheimer's or certain brain conditions, to find ways to help improve both breathing and brain health.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-10875715

• How vascular risk factors affect the risk of Alzheimer's disease after a stroke

  This study is looking at how things like high blood pressure, diabetes, and high cholesterol might affect the chances of stroke survivors developing Alzheimer's disease, so we can find better ways to help keep their brains healthy.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10875714

• Investigating the link between atrial fibrillation and Alzheimer's disease

  This study is looking at how atrial fibrillation (AF) might affect thinking and memory in people, even if they haven't had a stroke, by checking for certain markers in the blood that are linked to Alzheimer's disease, with the hope of finding new ways to help prevent and manage dementia for those with AF.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10561657

• Understanding how brain activity changes may drive Alzheimer’s disease progression in a mouse model

  Researchers are testing how changes in brain signals and protein cleanup processes affect the development of Alzheimer’s disease in mice.

  NIH research Nathan S. Kline Institute for Psych Res · Orangeburg, United States · NIH-11627965

• Thiamine-boosting therapy for Alzheimer’s: understanding how benfotiamine may reduce harmful AGE in DP patients

  A medication-based approach using high-dose vitamin B1 (benfotiamine) is studied to help people with Alzheimer's by reducing harmful sugar-related molecules.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11627145

• Non-invasive tears biomarker for early Alzheimer's in LMICs

  A low-cost, tear-based biomarker approach aims to detect early Alzheimer’s disease in older adults in Peru and similar settings.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11623923

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.